Code: S305472-100ML
Trimethyl orthoformate is a popular reagent used in chemical synthesis to prepare important building blocks. It is also employed in the manufacture of acetals to introduce the protective group for aldehydes. Using acid catalysts, acetals can be deprotected back to aldehyde.
per 100ML
Loading... Trimethyl orthoformate
Trimethyl orthoformate can be used:
To convert sulfonic acids to methyl esters.
To convert 2-acylcyclohexanones to the corresponding acetal derivatives.
To mediate Pinacol reaction of various 1,2-diols with tin(IV) chloride without the formation of water.
To synthesize 1-substituted-1H-1,2,3,4-tetrazoles via a three-component condensation with amine and sodium azide catalyzed by indium triflate under solvent-free conditions.
For the N-methylation of amines in the presence of sulfuric acid.
To convert sulfonic acids to methyl esters.
To convert 2-acylcyclohexanones to the corresponding acetal derivatives.
To mediate Pinacol reaction of various 1,2-diols with tin(IV) chloride without the formation of water.
To synthesize 1-substituted-1H-1,2,3,4-tetrazoles via a three-component condensation with amine and sodium azide catalyzed by indium triflate under solvent-free conditions.
For the N-methylation of amines in the presence of sulfuric acid.